[Sensitive and specific screening for detection of spina bifida by echography in the second trimester; systematic review and meta-analysis].
2000; National Institutes of Health; Volume: 144; Issue: 36 Linguagem: Inglês
Autores
Josephine M.I. Vos, Martin Offringa, C. M. Bilardo, Jeroen G. Lijmer, P. G. Barth,
Tópico(s)Fetal and Pediatric Neurological Disorders
ResumoEvaluation of the diagnostic accuracy of ultrasound in the second trimester for the detection of spina bifida.Systematic review and meta-analysis.Medline and Embase were searched to identify prospective studies in a general pregnant population. Also, in the Cochrane Library, references of identified reports and recent reviews were checked for relevant studies. Retrieved abstracts were selected independently by 2 authors using predefined criteria. Assessment of quality and generalizability of the included studies and data extraction were performed by 3 authors independently. The data were tested for heterogeneity and pooled estimates of sensitivity and specificity were calculated for all studies.13 studies were included. Specificity was approximately 100% in all cases. Sensitivity varied from 40% to 100%. The summary point estimate for sensitivity was 71% with a 95% confidence interval of 59%-81%.Ultrasound in the second trimester is a specific investigation to detect spina bifida, which may detect seven out of ten defects. Used as a screening tool, it could contribute to a significant reduction in the number of children born with spina bifida.
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