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Combining high dose external beam radiotherapy with a simultaneous integrated boost to the dominant intraprostatic lesion: Analysis of genito-urinary and rectal toxicity

2016; Elsevier BV; Volume: 119; Issue: 3 Linguagem: Inglês

10.1016/j.radonc.2016.04.031

1879-0887

Nora Sundahl, Gert De Meerleer, Geert Villeirs, Piet Ost, Wilfried De Neve, Nicolaas Lumen, Pieter De Visschere, M. Van Eijkeren, Valérie Fonteyne,

Prostate Cancer Treatment and Research

Local recurrences after radiotherapy are dose-dependent and occur in the dominant intraprostatic lesion (DIL). The purpose of this study was to evaluate the impact of a simultaneous integrated boost (SIB) to the magnetic resonance imaging (MRI)-defined DIL on toxicity.Four-hundred and ten patients were treated with intensity-modulated radiotherapy. A median dose of 78Gy was prescribed to the prostate. A SIB of 82Gy to the DIL was performed in 225 patients (SIB+). Genitourinary and rectal toxicity on fixed time points up to 8years were compared between SIB- (185 patients) and SIB+ patients. Chi-square, Fisher's exact and Kaplan-Meier statistics were applied. With a median follow up of 72months, the six-year actuarial risk of genitourinary and rectal toxicity grade⩾2 was 31% and 12% respectively. The actuarial risk of developing toxicity and incidence of symptoms at fixed time points were not increased with a SIB.Performing a SIB did not increase genitourinary or rectal toxicity up to 8years' follow-up.