[Inhibitory action of berberine on glucose absorption].
2003; National Institutes of Health; Volume: 38; Issue: 12 Linguagem: Inglês
Autores
Guoyu Pan, Guangji Wang, Jianguo Sun, Zhi‐Jiang Huang, Xiaochen Zhao, Yi Gu, Xiaodong Liu,
Tópico(s)Diet, Metabolism, and Disease
ResumoTo study the absorption characteristics of berberine and its influence on glucose absorption.Rat recirculating perfusion model was used to study berberine absorption characteristics and Caco-2 cell model was used to explore the influence of berberine on disaccharidase, using HPLC to assay the appearance of glucose to indicate enzyme activities.Berberine was found to be hardly absorbed in the intestine (less than 5% in 2.5 h). However, sucrase and maltase activities were found to be inhibited by berberine, its ID50 to sucrase is 1.830 mg.L-1, and showed no dose dependent influence on maltase activity. Berberine also showed influence on glucose absorption. However, this effect is not significant.Berberine may act as an alpha-glucosidase inhibitor, which is its main mechanism in diabetes treatment.
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