Genetic Damages of Nurses Exposed to Antineoplastic Agents
2003; National Environmental Health Association; Linguagem: Inglês
ISSN
0022-0892
Autores Tópico(s)Safe Handling of Antineoplastic Drugs
ResumoObjective To observe the genetic damages relate d to occupational exposure to antineoplastic agents without special protective measures in exposed subjects.Methods The damages of DNA and chromosomes of peripheral blood lym-phocytes were determined by comet assay and cytokinesis-block micronucleus test in exposure group consisting of24nurses oc-cupationally exposed to antineoplastic agents without special protective measures and control group consisting of24female doc-tors without exposure to antineoplastic agents in oncology department in a certain hospital.Results The exposure group showed significantly higher micronucleus rate(13.25‰±5.17‰)compared with that of control group(3.79‰±2.19‰),P0.01.The mean full length of comet in exposure group[(43.13±17.82)μm]was also significantly higher than that of control group[(27.52±5.69)μm],P0.01.Conclu sion The DNA and chromosomes of peripheral lymphocytes of nurses working in oncolo-gy department had been damaged in different degrees.
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