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FeSe 2 ‐Decorated Bi 2 Se 3 Nanosheets Fabricated via Cation Exchange for Chelator‐Free 64 Cu‐Labeling and Multimodal Image‐Guided Photothermal‐Radiation Therapy

2016; Wiley; Volume: 26; Issue: 13 Linguagem: Inglês

10.1002/adfm.201504810

1616-3028

Liang Cheng, Sida Shen, Sixiang Shi, Yi Yuan, Xiaoyong Wang, Guosheng Song, Kai Yang, Gang Liu, Todd E. Barnhart, Weibo Cai, Zhuang Liu,

Photoacoustic and Ultrasonic Imaging

Multifunctional theranostic agents have become rather attractive to realize image‐guided combination cancer therapy. Herein, a novel method is developed to synthesize Bi 2 Se 3 nanosheets decorated with mono‐dispersed FeSe 2 nanoparticles (FeSe 2 /Bi 2 Se 3 ) for tetra‐modal image‐guided combined photothermal and radiation tumor therapy. Interestingly, upon addition of Bi(NO 3 ) 3 , pre‐made FeSe 2 nanoparticles via cation exchange would be gradually converted into Bi 2 Se 3 nanosheets, on which remaining FeSe 2 nanoparticles are decorated. The yielded FeSe 2 /Bi 2 Se 3 composite‐nanostructures are then modified with polyethylene glycol (PEG). Taking advantages of the high r 2 relaxivity of FeSe 2 , the X‐ray attenuation ability of Bi 2 Se 3 , the strong near‐infrared optical absorbance of the whole nanostructure, as well as the chelate‐free radiolabeling of 64 Cu on FeSe 2 /Bi 2 Se 3 ‐PEG, in vivo magnetic resonance/computer tomography/photoacoustic/position emission tomography multimodal imaging is carried out, revealing efficient tumor homing of FeSe 2 /Bi 2 Se 3 ‐PEG after intravenous injection. Utilizing the intrinsic physical properties of FeSe 2 /Bi 2 Se 3 ‐PEG, in vivo photothermal and radiation therapy to achieve synergistic tumor destruction is then realized, without causing obvious toxicity to the treated animals. This work presents a unique method to synthesize composite‐nanostructures with highly integrated functionalities, promising not only for nano‐biomedicine but also potentially for other different nanotechnology fields.