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[Isolation and structure of wilfordlonging from Tripterygium wilfordii Hook. f].

2002; National Institutes of Health; Volume: 37; Issue: 2 Linguagem: Inglês

Sui Lin, Yuanchao Li, Nobuko Sakurai, Jianhong Cao, Si-sang Deng, Xia Zhi-lin, Di-lin Xie,

Natural product bioactivities and synthesis

To study the chemical composition of Tripterygirm wilfordii Hook. f.Colunm chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR, 13CNMR (COM and OFR), 1H-1H COSY, 1H-13C COSY, NOESY and COLOC spectra were used to determine the structures of the isolated constituents.Two sesquiterpene alkaloids were isolated and their structures were elucidated as wilforgine and wilfordlongine on the basis of spectral evidence.Wilfordclonine is a new sesquiterpene alkaloid.