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BIBTEX RIS

Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT

2016; Elsevier BV; Volume: 22; Issue: 8 Linguagem: Inglês

10.1016/j.cmi.2016.05.006

ISSN

1469-0691

Autores

Harald Hoffmann, Korkut Avsar, Ralf Göres, S Mavi, Sabine Hofmann-Thiel,

Tópico(s)

Advanced materials and composites

Resumo

QuantiFERON-TB Gold IT analyses interferon-γ release from CD4(+) T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8(+) T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.

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