Selective and Simultaneous Deprotection of Amine and Lactam Functions in the Syntheses of Pyridazino[4,5-b]oxazinones and Pyridazino[4,5-b]thiazinones
1993; Elsevier BV; Volume: 36; Issue: 3 Linguagem: Inglês
10.3987/com-92-6202
ISSN1881-0942
AutoresP師er M�yus, Erzs暫et Z�a-Kaczi�,
Tópico(s)Synthesis and Reactivity of Heterocycles
ResumoBenzyloxymethyl (BOM) and benzyl (Bz) groups were employed for protection of the amide-and amino-nitrogens in the title compounds.The BOM protective group could be removed selectively or simultaneously with the Bz group depending on the reaction conditions.By catalytic hydrogenation of the fully protected pyridazinooxazinone (lb), unexpectedly the 4-methyl derivative (le) could also be prepared.The mechanism for the formation of l e is also discussed.
Referência(s)