On the necessity of new decision-making methods for cancer-associated, symptomatic, pulmonary embolism
2016; Elsevier BV; Volume: 143; Linguagem: Inglês
10.1016/j.thromres.2016.05.010
ISSN1879-2472
AutoresAlberto Carmona‐Bayonas, Carme Font, Paula Jiménez‐Fonseca, Francisco J. Fenoy, Remedios Otero, Carmen Beato, Juan Alberto Díaz Plasencia, M. Biosca, Marcelo Sánchez, Mariana Benegas, David Calvo-Temprano, Diego Varona Porres, L. Fáez, María Ángeles Vicente, I. de la Haba, Maite Antonio, Olga Madridano, Avinash Ramchandani, Eduardo Castañón, Pablo Javier Marchena, Mari José Martínez, M. Martín, Gabriel Marín, Francisco Ayala de la Peña, Vicente Vicente,
Tópico(s)Meta-analysis and systematic reviews
ResumoBackground Acute symptomatic pulmonary embolism (PE) varies in its clinical manifestations in patients with cancer and entails specific issues. The objective is to assess the performance of five scores (PESI, sPESI, GPS, POMPE, and RIETE) and a clinical decision rule to predict 30-day mortality. Methods This is an ambispective, observational, multicenter study that collected episodes of PE in patients with cancer from 13 Spanish centers. The main criterion for comparing scales was the c-indices and 95% confidence intervals (CIs) of the models for predicting 30-day mortality. Results 585 patients with acute symptomatic PE were recruited. The 30-day mortality rate was 21.3 (95% CI; 18.2–24.8%). The specific scales (POMPE-C and RIETE) were equally effective in discriminating prognosis (c-index of 0.775 and 0.757, respectively). None of these best performing scales was superior to the ECOG-PS with a c-index of 0.724. The remaining scores (PESI, sPESI, and GPS) performed worse, with c-indexes of 0.719, 0.705, and 0.722, respectively. The dichotomic "clinical decision rule" for ambulatory therapy was at least equally reliable in defining a low risk group: in the absence of all exclusion criteria, 30-day mortality was 2%, compared to 5% and 4% in the POMPE-C and RIETE low-risk categories, respectively. Conclusion The accuracy of the five scales examined was not high enough to rely on to predict 30-day mortality and none of them contribute significantly to qualitative clinical judgment.
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