Mechanism of action of bleomycin—I
1972; Elsevier BV; Volume: 21; Issue: 12 Linguagem: Inglês
10.1016/0006-2952(72)90073-1
ISSN1873-2968
AutoresPriscilla P. Saunders, Gloria A. Schultz,
Tópico(s)RNA and protein synthesis mechanisms
ResumoExperiments have been carried out demonstrating the inhibition of Bacillus subtilis with bleomycin. The antibiotic was highly inhibitory to non-proliferating cells as well as growing cells. A recombination-deficient (rec−) strain of B. subtilis behaved differently in the presence of bleomycin than did the respective wild type organism. The wild type cells were able to recover from lower levels of bleomycin while the rec− strain was not. A bleomycin-resistant strain of B. subtilis was isolated and found to be cross-resistant to mitomycin C but not to daunomycin.
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