Portal de Periódicos da CAPES

Effectiveness and utility of hyaluronic acid in osteoarthritis

2015; CIC Edizioni Internazionali; Linguagem: Inglês

10.11138/ccmbm/2015.12.1.031

1971-3266

Alberto Migliore, Simone Procopio,

Inflammatory mediators and NSAID effects

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular hyaluronic acid is a treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, but potentially should apply to all synovial joints in order to reduce pain and improve joint lubrication. Exogenous HA can enhance chondrocyte HA synthesis, prevent the degradation of cartilage and promote its regeneration. Moreover it can reduce the production of proinflammatory mediators and matrix metalloproteinases involved in OA pathogenesis. This mini review highlights the evidence of hyaluronic acid in reducing osteoarthritis symptoms and structural damage, as well as its ability to delay prosthetic surgery. Viscosupplementation should be considered as a long-term therapy.