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Effects of GABA-Receptor Stimulation and Blockade on Micturition in Normal Rats and Rats with Bladder Outflow Obstruction

1993; Lippincott Williams & Wilkins; Volume: 150; Issue: 2 Part 1 Linguagem: Inglês

10.1016/s0022-5347(17)35542-8

1527-3792

Yasuhiko Igawa, Anders Mattiasson, Karl‐Erik Andersson,

Anesthesia and Pain Management

No AccessJournal of Urology1 Aug 1993Effects of GABA-Receptor Stimulation and Blockade on Micturition in Normal Rats and Rats with Bladder Outflow Obstruction Yasuhiko Igawa, Anders Mattiasson, and Karl-Erik Andersson Yasuhiko IgawaYasuhiko Igawa , Anders MattiassonAnders Mattiasson , and Karl-Erik AnderssonKarl-Erik Andersson View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35542-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The effects on micturition of the GABA receptor agonists muscimol (selective for GABAA - receptors) and baclofen (selective for GABAB-receptors), given intrathecally and intra-arterially to unanesthetized rats with and without bladder hypertrophy secondary to outflow obstruction, were studied by continuous cystometry. When given intrathecally in increasing doses, both muscimol (1 to 10μg.) and baclofen (0.1 to 5μg.) produced a dose-dependent inhibition of micturition with progressive increases in bladder capacity and residual volume, and a decrease in micturition pressure ending with urinary retention and dribbling incontinence. Generally, the effects were similar in normal rats and rats with bladder hypertrophy. In normal rats, bicuculline (blocking GABAA- receptors) decreased bladder capacity and micturition volume, and increased micturition pressure. In both types of rat, the effects of muscimol and baclofen were partly counteracted by bicuculline and saclofen, respectively. In rats with bladder hypertrophy, the amplitude of the spontaneous bladder contractions during filling was significantly increased after administration of muscimol and baclofen. When given intra-arterially in high doses, muscimol (2 to 16mg./kg.) and baclofen (8 to 16mg./kg.) produced effects on cystometric parameters and spontaneous bladder contractions similar to those obtained with intrathecal administration. These results suggest that muscimol and baclofen have insignificant peripheral effects on the lower urinary tract, but depress micturition by an effect on the central nervous system. They also suggest that the inhibitory GABA-ergic system does not play a role in the genesis of bladder hyperactivity in rats with outflow obstruction. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byMatsuta Y, Yusup A, Tanase K, Ishida H, Akino H and Yokoyama O (2010) Melatonin Increases Bladder Capacity via GABAergic System and Decreases Urine Volume in RatsJournal of Urology, VOL. 184, NO. 1, (386-391), Online publication date: 1-Jul-2010.Miyazato M, Sasatomi K, Hiragata S, Sugaya K, Chancellor M, de Groat W and Yoshimura N (2008) GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured RatsJournal of Urology, VOL. 179, NO. 3, (1178-1183), Online publication date: 1-Mar-2008.MIYAZATO M, SUGAYA K, NISHIJIMA S, ASHITOMI K, MOROZUMI M and OGAWA Y (2018) DIETARY GLYCINE INHIBITS BLADDER ACTIVITY IN NORMAL RATS AND RATS WITH SPINAL CORD INJURYJournal of Urology, VOL. 173, NO. 1, (314-317), Online publication date: 1-Jan-2005.MIYAZATO M, SUGAYA K, NISHIJIMA S, ASHITOMI K, OHYAMA C and OGAWA Y (2018) Rectal Distention Inhibits Bladder Activity Via Glycinergic and Gabaergic Mechanisms in RatsJournal of Urology, VOL. 171, NO. 3, (1353-1356), Online publication date: 1-Mar-2004.PEHRSON R, LEHMANN A and ANDERSSON K (2018) Effects of γ-Aminobutyrate B Receptor Modulation on Normal Micturition and Oxyhemoglobin Induced Detrusor Overactivity in Female RatsJournal of Urology, VOL. 168, NO. 6, (2700-2705), Online publication date: 1-Dec-2002.PEHRSON R and ANDERSSON K (2018) Effects Of Tiagabine, A γ-Aminobutyric Acid Re-Uptake Inhibitor, on Normal Rat Bladder FunctionJournal of Urology, VOL. 167, NO. 5, (2241-2246), Online publication date: 1-May-2002.Watanabe T, Perkash I and Constantinou C (2018) Modulation of Detrusor Contraction Strength and Micturition Characteristics by Intrathecal Baclofen in Anesthetized RatsJournal of Urology, VOL. 157, NO. 6, (2361-2365), Online publication date: 1-Jun-1997.Igawa Y, Mattiasson A and Andersson K (2018) Micturition and Premicturition Contractions in Unanesthetized Rats with Bladder Outlet ObstructionJournal of Urology, VOL. 151, NO. 1, (244-249), Online publication date: 1-Jan-1994. Volume 150Issue 2 Part 1August 1993Page: 537-542 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.KeywordsGABAurethral obstructionratsbladderhypertrophyMetrics Author Information Yasuhiko Igawa More articles by this author Anders Mattiasson More articles by this author Karl-Erik Andersson More articles by this author Expand All Advertisement PDF downloadLoading ...