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Codonopiloneolignanin A, a polycyclic neolignan with a new carbon skeleton from the roots of Codonopsis pilosula

2015; Elsevier BV; Volume: 27; Issue: 1 Linguagem: Inglês

10.1016/j.cclet.2015.11.009

1878-5964

Yueping Jiang, Qing‐Lan Guo, Yufeng Liu, Jian‐Gong Shi,

Natural product bioactivities and synthesis

A neolignan codonopiloneolignanin A (1) with a novel 2,9:2ʹ,9:7,7ʹ-tricyclo-8,9ʹ-neolignane skeleton was isolated from an aqueous extract of the Codonopsis pilosula roots. Its structure including the absolute configuration was elucidated by extensive spectroscopic analysis, including 2D NMR and electronic circular dichroism calculation. The proposed biosynthetic pathway of compound 1 is also discussed.