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Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence

1990; American Psychiatric Association Publishing; Volume: 2; Issue: 3 Linguagem: Inglês

10.1176/jnp.2.3.268

1545-7222

Edwin H. Cook, Bennett Leventhal, Wendy Heller, John Metz, Mark S. Wainwright, Daniel X. Freedman,

Child Nutrition and Feeding Issues

Back to table of contents Previous article Next article No AccessAutistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligencePublished Online:1 Apr 2006https://doi.org/10.1176/jnp.2.3.268AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractWhole-blood serotonin (5-HT) and plasma norepinephrine (NE) were studied in 16 autistic children, 21 siblings of autistic children, and 53 parents of autistic children. Both plasma NE and whole-blood 5-HT were negatively correlated with vocabulary performance. Whole-blood 5- HT and plasma NE did not differ between autistic children with or without histories of self-injurious behavior or decreased pain sensitivity. Eighteen subjects were hyperserotonemic (whole-blood 5-HT greater than 270 ng/ml). For these subjects, plasma NE was significantly higher than for subjects without hyperserotonemia. Seven of 10 families with one hyperserotonemic member had two or more hyperserotonemic members. Observations of familiarity of whole-blood 5- HT suggest that larger-scale and more focused study of whole-blood 5-HT as a possible genetic marker may be productive. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences $35.00 Add to cart PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. 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