Left Ventricular Ejection Fraction for Sudden Death Risk Stratification and Guiding Implantable Cardioverter-defibrillators Implantation
2010; Lippincott Williams & Wilkins; Volume: 55; Issue: 5 Linguagem: Inglês
10.1097/fjc.0b013e3181d9f49c
ISSN1533-4023
AutoresAlfred E. Buxton, Kristin Ellison, Peem Lorvidhaya, Ohad Ziv,
Tópico(s)Cardiac Arrhythmias and Treatments
ResumoCurrent guidelines for use of implantable cardioverter-defibrillators (ICDs) for primary prevention of sudden death in patients with coronary disease and nonischemic dilated cardiomyopathy are based primarily on ejection fraction (EF) 35% as a group are at lower risk for sudden death, these patients are not uniform with regard to other prognostic variables. A variety of tests, including measures of reduced repolarization reserve and measures of altered sympathetic/parasympathetic balance, have identified patients with EF >35% at relatively high risk for sudden death. One explanation for this "disconnect" is that there is no evidence of any direct mechanistic link between low EF and mechanisms responsible for ventricular tachyarrhythmias.
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