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Reed-Sternberg Cell Leukaemia

1981; SAGE Publishing; Volume: 67; Issue: 1 Linguagem: Inglês

10.1177/030089168106700112

2038-2529

Paola Cavalli, Mario Cazzola, Paolo G. Gobbi, M Gorini, A. Malfitano, Alberto Riccardi, Edoardo Ascari,

Glycosylation and Glycoproteins Research

A case of Reed-Sternberg (R-S) leukaemia is described, and the results of the morphological, cytochemical and cytokinetic studies on the circulating neoplastic cells are reported. Detailed data are given for each of the 3 types of abnormal circulating cells: abnormal mononuclear (AM) cells, Hodgkin's (H) cells and R-S cells. Our results cannot discriminate whether R-S cells derive from monocyte-macrophages or from B-cell lineage. However, some data suggest that H and R-S cells may likely originate from AM cells. The unfavourable clinical significance of the appearance of circulating R-S cells is discussed taking into account the other few cases reported in literature.