Mannose-Sensitive Adherence of Escherichia Coli to Epithelial Cells from Women with Recurrent Urinary Tract Infections
1984; Lippincott Williams & Wilkins; Volume: 131; Issue: 5 Linguagem: Inglês
10.1016/s0022-5347(17)50706-5
ISSN1527-3792
AutoresAnthony J. Schaeffer, Joan S. Chmiel, James L. Duncan, Walter S. Falkowski,
Tópico(s)Adolescent Sexual and Reproductive Health
ResumoNo AccessJournal of Urology1 May 1984Mannose-Sensitive Adherence of Escherichia Coli to Epithelial Cells from Women with Recurrent Urinary Tract Infections Anthony J. Schaeffer, Joan S. Chmiel, James L. Duncan, and Walter S. Falkowski Anthony J. SchaefferAnthony J. Schaeffer More articles by this author , Joan S. ChmielJoan S. Chmiel More articles by this author , James L. DuncanJames L. Duncan More articles by this author , and Walter S. FalkowskiWalter S. Falkowski More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50706-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The effect of D-mannose on adherence of 73 Escherichia coli strains to vaginal and buccal epithelial cells from women with recurrent urinary tract infections, and on agglutination of human and guinea pig erythrocytes was tested. Urinary, vaginal or anal isolates from women with such infections were used. Of the strains 66 (90 per cent) demonstrated adherence to epithelial cells. D-mannose inhibited completely the adherence of 25 strains (42 per cent) that adhered to vaginal cells and inhibited an additional 11 strains (18 per cent) by at least 50 per cent. Similar results were obtained with buccal cells. The inhibitory effect of D-mannose was similar regardless of the origin of the strains. Hemagglutination frequently was inhibited by D-mannose but no consistent association between hemagglutination, and epithelial cell adherence and the effect of D-mannose was observed. The results suggest that mannose-sensitive as well as mannose-resistant adhesins frequently mediate Escherichia coli adherence to vaginal epithelial cells, and may contribute to vaginal colonization and cystitis. © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByRoberts J (2018) Tropism in Bacterial Infections: Urinary Tract InfectionsJournal of Urology, VOL. 156, NO. 5, (1552-1559), Online publication date: 1-Nov-1996. Volume 131Issue 5May 1984Page: 906-910 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony J. Schaeffer More articles by this author Joan S. Chmiel More articles by this author James L. Duncan More articles by this author Walter S. Falkowski More articles by this author Expand All Advertisement Loading ...
Referência(s)