Portal de Periódicos da CAPES

Effect of Intravesical Administration of Tumor Necrosis Serum and Human Recombinant Tumor Necrosis Factor on a Murine Bladder Tumor

1987; Lippincott Williams & Wilkins; Volume: 138; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(17)43179-x

1527-3792

Kan-ei Lee, Robert O’Donnell, Susan R. Schoen, Abraham T.�K. Cockett,

Adenosine and Purinergic Signaling

No AccessJournal of Urology1 Aug 1987Effect of Intravesical Administration of Tumor Necrosis Serum and Human Recombinant Tumor Necrosis Factor on a Murine Bladder Tumor Kan-Ei Lee, Robert W. O’Donnell, Susan Schoen, and Abraham T.K. Cockett Kan-Ei LeeKan-Ei Lee More articles by this author , Robert W. O’DonnellRobert W. O’Donnell More articles by this author , Susan SchoenSusan Schoen More articles by this author , and Abraham T.K. CockettAbraham T.K. Cockett More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43179-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The effect of intravesical administration of tumor necrosis factor (TNF) on the implantability and growth of bladder cancer was studied using the murine tumor model, MBT-2. Crude TNF was prepared from serum (TNS) of BCG infected rats after injection of endotoxin or the recombinant product of human TNF-alpha was used. Treatment was begun 24 hr. or seven days after tumor instillation and repeated three times. Tumor implantability and tumor weight were determined on day 21. Low dose TNF (200 U), given in the form of TNS, failed to suppress the growth of established tumors (seven-day tumor). It did, however, significantly reduce tumor implantability. The growth of seven-day tumors was significantly suppressed by administration of higher dose of TNF (3,700 U) given in recombinant form. (J. Urol., 138: 430-432, 1987) © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byVan Moorselaar R, Hendriks B, Borm G, Van Der Meide P, Debruyne F and Schalken J (2018) Inhibition of Rat Bladder Tumor (Rbt323) Growth by Tumor Necrosis Factor Alpha and Interferon-Gamma in VivoJournal of Urology, VOL. 148, NO. 2 Part 1, (458-462), Online publication date: 1-Aug-1992.Steinberg G, Brendler C, Squire R and Isaacs J (2018) Experimental Intravesical Therapy for Superficial Transitional Cell Carcinoma in a Rat Bladder Tumor ModelJournal of Urology, VOL. 145, NO. 3, (647-653), Online publication date: 1-Mar-1991.Bahnson R and Ratliff T (2018) In Vitro and in Vivo Anti-Tumor Activity of Recombinant Mouse Tumor Necrosis Factor (TNF) in a Mouse Bladder Tumor (MBT-2)Journal of Urology, VOL. 144, NO. 1, (172-175), Online publication date: 1-Jul-1990.Amano T, Kumini K, Nakashima K, Uchibayashi T and Hisazumi H (2018) A Combined Therapy of Hyperthermia and Tumor Necrosis Factor for Nude Mice Bearing KK-47 Bladder CancerJournal of Urology, VOL. 144, NO. 2 Part 1, (370-374), Online publication date: 1-Aug-1990. Volume 138Issue 2August 1987Page: 430-432 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Kan-Ei Lee More articles by this author Robert W. O’Donnell More articles by this author Susan Schoen More articles by this author Abraham T.K. Cockett More articles by this author Expand All Advertisement PDF downloadLoading ...