Portal de Periódicos da CAPES

New findings in HCV genotype distribution in selected West European, Russian and Israeli regions

2016; Elsevier BV; Volume: 81; Linguagem: Inglês

10.1016/j.jcv.2016.05.010

1873-5967

Vladimir Kartashev, Matthias Döring, Leonardo Nieto, Eleda Coletta, Rolf Kaiser, Saleta Sierra, A. Guerrero, Heribert Stoiber, Christian Paar, Anne–Mieke Vandamme, Frederik Nevens, Marc Van Ranst, Lize Cuypers, P. Braun, Robert Ehret, Martin Obermeier, Sebastian Schneeweiß, Stefan Scholten, Konstanze D. Römer, K Isernhagen, Nishat Tasnim Qurashi, Eva Heger, Elena Knops, Maria Neumann‐Fraune, Jörg Timm, Andreas Walker, Nadine Lübke, Heiner Wedemeyer, Julian Schulze zur Wiesch, Marc Lütgehetmann, Susanne Polywka, Martin Däumer, Dieter Hoffmann, Ulrike Protzer, Nadia Marascio, Alfredo Focà, Maria Carla Liberto, Giorgio Settimo Barreca, Luisa Galati, Carlo Torti, Vincenzo Pisani, Carlo Federico Perno, Francesca Ceccherini‐Silberstein, Valeria Cento, M. Ciotti, Maurizio Zazzi, Barbara Rossetti, Andrea De Luca, C. Caudai, Orna Mor, Carole Seguin‐Devaux, Thérèse Staub, Fernando Araújo, Perpétua Gómes, Joaquim Cabanas, Nikolay Markin, Ю. Г. Хоменко, M. V. Govorukhina, G.I. Lugovskaya, Д. В. Донцов, Antonio Más, Elisa Martró, Verónica Saludes, Francisco Rodríguez‐Frías, Féderico García, Paz Casas, Alberto de la Iglesia, Juan Carlos Alados, María José Pena-López, Mario Rodríguez-Domínguez, Juan Carlos Galán, Adolfo Suárez, Laura Cardeñoso, Michelle Guerrero, C. Vegas-Dominguez, J. Blas-Espada, Rafael Rubio, Silvia García‐Bujalance, Laura Benítez‐Gutiérrez, Carmen de Mendoza, Natalia Montiel, José Ramón Santos, Isabel Viciana, Ana Sofia Delgado, P.A. Martínez-Sanchez, Miriam Fernández‐Alonso, Gabriel Reina, Matilde Trigo, Miguel Echeverria, Antonio Aguilera, Daniel Navarro, Samuel Bernal, María Constanza Lozano, Felipe Fernández-Cuenca, Antonio Orduña, José Marı́a Eiros Bouza, Raúl Ortíz de Lejarazu, Ana Martínez-Sapiña, Andrés García‐Díaz, Tanzina Haque,

Hepatitis B Virus Studies

HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT).Analysis of epidemiological information and viral GT from patients undergoing viral genotyping in 2011-2015.Anonymized information from 52 centers was analyzed retrospectively.37,839 samples were included in the study. We show that the GT distribution is similar throughout Western European countries, with some local differences. Here GTs 1 and 2 prevalences are lower and of GT4 higher than in all previous reports. Israel has a unique GT pattern and in South Russia the GT proportions are more similar to Asia. GTs 5 and 6 were detected in very low proportions. Three cases of the recombinant genotype P were reported in Munich (Germany). In addition, we observed that GT proportion was dependant on patientś gender, age and transmission route: GTs 1b and 2 were significantly more common in female, older, nosocomially-infected patients, while GTs 1a, 3 and 4 were more frequent in male, younger patients infected by tattooing, drug consume, and/or sexual practices. In infections acquired by drug consume, GTs 1a (35.0%) and 3 (28.1%) prevailed. In infections related to sexual practices lower proportion of GT3 (14.0%) and higher of GT4 (20.2%) were detected. GT4 was mostly abundant in MSM (29.6%). HIV coinfection was significantly associated with higher proportions GTs 1a and 4 (42.5% and 19.3%, respectively).Genotype prevalence evolves and correlates to epidemiological factors. Continuous surveillance is necessary to better assess hepatitis C infection in Europe and to take appropriate actions.