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Biperiden Administration During REM Sleep Deprivation Diminished the Frequency of REM Sleep Attempts

1992; Oxford University Press; Volume: 15; Issue: 3 Linguagem: Inglês

10.1093/sleep/15.3.252

1550-9109

Rafael J. Salín-Pascual, Daniel Grandos-Fuentes, Lourdes Galicia-Polo, Estela Nieves, Timothy Roehrs, Thomas Roth,

Circadian rhythm and melatonin

Sixteen subjects were assigned to a group using either placebo or biperiden, with eight subjects in each group. Both groups were studied for one acclimatization night, one baseline night, four nights of rapid eye movement (REM) sleep deprivation and two recovery nights. All the subjects received either placebo or 4 mg biperiden 1 hour before sleep during the four nights of REM sleep deprivation. During the baseline and the recovery nights both groups received placebo capsules.