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Measurement of hypothalamic corticotropin-releasing factors in hypophyseal portal blood.

1985; National Institutes of Health; Volume: 44; Issue: 1 Pt 2 Linguagem: Inglês

Gibbs Dm,

Neuroendocrine regulation and behavior

Among the putative hypothalamic hormones that can influence the release of adrenocorticotropin (ACTH) in vitro, the 41-amino-acid corticotropin-releasing factor, oxytocin, vasopressin, and epinephrine were identified in hypophyseal portal plasma. Measurement of these substances in several situations associated with changes in ACTH secretion provided data consistent with a physiological role for all four hormones and suggested that control of the hypothalamo-hypophyseal-adrenal axis can be accomplished in different ways in response to different types of stimuli.