Follicular center-cell lymphoma with plasmacytic differentiation, monoclonal paraprotein, and peripheral blood involvement
1985; Lippincott Williams & Wilkins; Volume: 9; Issue: 10 Linguagem: Inglês
10.1097/00000478-198510000-00009
ISSN1532-0979
AutoresJohn F. Vago, Paul E. Hurtubise, Mary M. Redden-Borowsk, Orlando J. Martelo, Steven H. Swerdlow,
Tópico(s)Renal Diseases and Glomerulopathies
ResumoA patient with a nodular and diffuse smallcleaved follicular center-cell lymphoma that exhibited definite plasmacytic differentiation, a related monoclonal gammopathy, and circulating population of small lymphocytes is presented. Aside from showing that the presence of numerous plasma cells is not a reliable criterion for the diagnosis of a reactive follicular proliferation, the case is an example of a lymphoma without a block in maturation. The “neoplastic” B-cells show development to follicular center cells and beyond, to functioning plasma cells, and probably also to recirculating “memory” cells. It also suggests that plasmacytoid lymphocytic lymphomas (Lukes-Collins classification) might represent a heterogeneous group of lymphoid neoplasms with some closely related to follicular center-cell lymphomas and others more closely related to small lymphocytic lymphoma/B-cell chronic lymphocytic leukemia.
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