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Effect of "Toki" (Angelica acutiloba KITAGAWA) Extracts on Writhing and Capillary Permeability in Mice : Analgesic and Antiinflammatory Effects

1971; Pharmaceutical Society of Japan; Volume: 91; Issue: 10 Linguagem: Inglês

10.1248/yakushi1947.91.10_1098

1347-5231

Shigeo Tanaka, Yoshihiro Kano, Mamoru Tabata, Masao Konoshima,

Phytochemistry and Biological Activities

Analgesic and antiinflammatory effects of "Toki" (the root of Angelica acutiloba KITAGAWA) inferred from the literatures of Chinese medicine were investigated by the Whittle method. The results of the experiments clearly showed that the aqueous extract of Toki administered orally to mice inhibitedboth writhing and capillary permeability, suggesting an analgesic effect and an anti inflammatory effect, respectively. Toki extract was 1.7 times more effective than sodium acetylsalicylate regarding writhing inhibition, on the basis of the dry weight of Toki root. As for the inhibition of capillary permeability, Toki extract was 1.1 times as effective as sodium acetylsalicylate. It may be estimated from the above results that the analgesic effect expected from the daily dose of Toki used in prescription of Chinese medicine would be equivalent or even more effective as compared with acetylsalicylate. Chemical separation of "Toki" extract was carried out to examine the active components. The analgesic activity was mainly found in Fraction 6 (Chart 1), whereas a higher inhibitory activity on capillary permeability was observed in Fraction 7.