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Experimental infection of African green monkeys and cynomolgus monkeys with a SIVAGM strain isolated from a healthy African green monkey.

1990; National Institutes of Health; Volume: 19; Issue: 1 Linguagem: Inglês

S Honjo, Tadashi Narita, Ryou Kobayashi, Akio Hiyaoka, K. Fujimoto, MASAO TAKASAKA, Ippei Sakakibara, R Mukai, Koichi Ishikawa, Yoshihiro Ohta,

Immune Cell Function and Interaction

An infection occurred in all African green monkeys and cynomolgus monkeys experimentally inoculated with SIVAGM [TYO-1], as demonstrated by the appearance of an antibody to SIVAGM [TYO-1] and the isolation of the virus. No monkey exhibited overt clinical disorders throughout the experimental period of 42 weeks. Thus, SIVAGM was not pathogenic to its original host or to macaques. This system is proposed as a model for HIV infection manifesting no overt disease.