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A Multicenter Randomized Trial Comparing the Luteinizing Hormone-Releasing Hormone Analogue Goserelin Acetate Alone and with Flutamide in the Treatment of Advanced Prostate Cancer

1991; Lippincott Williams & Wilkins; Volume: 146; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)38080-1

1527-3792

C. Tyrrell, J. E. Altwein, F. Klippel, Eberhard Varenhorst, G. Lunglmayr, Francesco Boccardo, I.M. Holdaway, Jacques‐Antoine Haefliger, J. P. Jordaan,

Estrogen and related hormone effects

No AccessJournal of Urology1 Nov 1991A Multicenter Randomized Trial Comparing the Luteinizing Hormone-Releasing Hormone Analogue Goserelin Acetate Alone and with Flutamide in the Treatment of Advanced Prostate Cancer C.J. Tyrrell, J.E. Altwein, F. Klippel, E. Varenhorst, G. Lunglmayr, F. Boccardo, I.M. Holdaway, J.-M. Haefliger, J.P. Jordaan, M. Sotarauta, and International Prostate Cancer Study Group† C.J. TyrrellC.J. Tyrrell More articles by this author , J.E. AltweinJ.E. Altwein More articles by this author , F. KlippelF. Klippel More articles by this author , E. VarenhorstE. Varenhorst More articles by this author , G. LunglmayrG. Lunglmayr More articles by this author , F. BoccardoF. Boccardo More articles by this author , I.M. HoldawayI.M. Holdaway More articles by this author , J.-M. HaefligerJ.-M. Haefliger More articles by this author , J.P. JordaanJ.P. Jordaan More articles by this author , M. SotarautaM. Sotarauta More articles by this author , and International Prostate Cancer Study Group† K.-F. Klippel, Celle, J. E. Altwein and A. Leitenberger, Munich, K. Wind, Landau, N. Jaeger, Bonn, M. Knöener, Hannover and K. Stockamp, Ludwighasen, Germany; E. Varenhorst and H. Hjertberg, Norrköping, C. Nyman and R. Stege, Stockholm, I. Wall, Vastervik, A. Gottfries, Eskilstuna, F. Lyrdal, Eksjö, R. Lundgren, Lund and L. Brote, Motala, Sweden; G. Lunglmayr, Mistelbach and W. Kuber, Oberworst, Austria; C. J. Tyrrell, J. Hammonds, R. G. A. Choa and F. Daniel, Plymouth, United Kingdom; F. Boccardo and L. Giuliani, Genova, E. Bezzi, Parma, F. Selvaggi, Bari and other investigators of the PONCAP group, Italy; I. M. Holdaway, Auckland, New Zealand; J. P. Jordaan, Durban and H. Pierneef, Tygerberg, South Africa; J.-M. Haefliger, La Chaux de Fonds, Switzerland; M. Sotarauta, Kuopio, Finland and J. Heaney, Dublin, Ireland. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38080-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A prospective randomized trial was conducted to compare the effects of the nonsteroidal antiandrogen flutamide (250mg. 3 times daily) plus the luteinizing hormone-releasing hormone analogue goserelin acetate (Zoladex) (3.6mg. subcutaneous depot injection every 28 days) with goserelin acetate alone in advanced prostatic carcinoma. A total of 571 eligible patients, of whom 57% had distant metastases, showed no difference in subjective or objective response rates, interval to progression, treatment failure or survival after a median followup of 2 years. In the combination group more patients had an early decrease in elevated levels of tumor markers and the small number of patients with an increase in signs and symptoms within the first 4 weeks showed a significant decrease. However, increased gastrointestinal and hepatic toxicity in the combination group resulted in 44 patients being withdrawn from the trial. These results indicate that the combination of goserelin acetate with flutamide provides no long-term clinical benefit in patients with advanced prostatic carcinoma compared to goserelin acetate alone. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByPENSON D, RAMSEY S, VEENSTRA D, CLARKE L, GANDHI S and HIRSCH M (2018) THE COST-EFFECTIVENESS OF COMBINED ANDROGEN BLOCKADE WITH BICALUTAMIDE AND LUTEINIZING HORMONE RELEASING HORMONE AGONIST IN MEN WITH METASTATIC PROSTATE CANCERJournal of Urology, VOL. 174, NO. 2, (547-552), Online publication date: 1-Aug-2005.SCHERR D, PITTS W and VAUGHAN E (2018) DIETHYLSTILBESTEROL REVISITED: ANDROGEN DEPRIVATION, OSTEOPOROSIS AND PROSTATE CANCERJournal of Urology, VOL. 167, NO. 2 Part 1, (535-538), Online publication date: 1-Feb-2002.KAISARY A, BOWSHER W, GILLATT D, ANDERSON J, MALONE P and IMBIMBO B (2018) PHARMACODYNAMICS OF A LONG ACTING DEPOT PREPARATION OF AVORELIN IN PATIENTS WITH PROSTATE CANCERJournal of Urology, VOL. 162, NO. 6, (2019-2023), Online publication date: 1-Dec-1999.Eri L and Tveter K (2018) Safety, Side Effects and Patient Acceptance of the Luteinizing Hormone Releasing Hormone Agonist Leuprolide in Treatment of Benign Prostatic HyperplasiaJournal of Urology, VOL. 152, NO. 2 Part 1, (448-452), Online publication date: 1-Aug-1994.Dankoff J (2018) Near Fatal Liver Dysfunction Secondary to Administration of Flutamide for Prostate CancerJournal of Urology, VOL. 148, NO. 6, (1914-1914), Online publication date: 1-Dec-1992. Volume 146Issue 5November 1991Page: 1321-1326 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.KeywordscarcinomaLH-FSH releasing hormoneflutamideprostatic neoplasmsanilidesMetricsAuthor Information C.J. Tyrrell More articles by this author J.E. Altwein More articles by this author F. Klippel More articles by this author E. Varenhorst More articles by this author G. Lunglmayr More articles by this author F. Boccardo More articles by this author I.M. Holdaway More articles by this author J.-M. Haefliger More articles by this author J.P. Jordaan More articles by this author M. Sotarauta More articles by this author International Prostate Cancer Study Group† K.-F. Klippel, Celle, J. E. Altwein and A. Leitenberger, Munich, K. Wind, Landau, N. Jaeger, Bonn, M. Knöener, Hannover and K. Stockamp, Ludwighasen, Germany; E. Varenhorst and H. Hjertberg, Norrköping, C. Nyman and R. Stege, Stockholm, I. Wall, Vastervik, A. Gottfries, Eskilstuna, F. Lyrdal, Eksjö, R. Lundgren, Lund and L. Brote, Motala, Sweden; G. Lunglmayr, Mistelbach and W. Kuber, Oberworst, Austria; C. J. Tyrrell, J. Hammonds, R. G. A. Choa and F. Daniel, Plymouth, United Kingdom; F. Boccardo and L. Giuliani, Genova, E. Bezzi, Parma, F. Selvaggi, Bari and other investigators of the PONCAP group, Italy; I. M. Holdaway, Auckland, New Zealand; J. P. Jordaan, Durban and H. Pierneef, Tygerberg, South Africa; J.-M. Haefliger, La Chaux de Fonds, Switzerland; M. Sotarauta, Kuopio, Finland and J. Heaney, Dublin, Ireland. More articles by this author Expand All Advertisement Loading ...