Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection
2016; Elsevier BV; Volume: 41; Linguagem: Inglês
10.1016/j.ceb.2016.05.003
ISSN1879-0410
AutoresNathan L. Meyers, Krystal A. Fontaine, G. Renuka Kumar, Mélanie Ott,
Tópico(s)Diabetes and associated disorders
ResumoHepatitis C virus (HCV) is a major cause of liver disease worldwide. To establish and maintain chronic infection, HCV extensively rearranges cellular organelles to generate distinct compartments for viral RNA replication and virion assembly. Here, we review our current knowledge of how HCV proliferates and remodels ER-derived membranes while preserving and expanding associated lipid droplets during viral infection. Unraveling the molecular mechanisms responsible for HCV-induced membrane reorganization will enhance our understanding of the HCV life-cycle, the associated liver pathology, and the biology of the ER:lipid droplet interface in general.
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