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Heparinoid-induced inhibition of aldosterone secretion in pregnant women

1971; Elsevier BV; Volume: 109; Issue: 7 Linguagem: Inglês

10.1016/0002-9378(71)90274-2

1097-6868

Edward N. Ehrlich,

Pregnancy and preeclampsia studies

Aldosterone secretion is strikingly elevate during normal pregnancy. In order to study the role of the increased aldosterone in sodium conservation, aldosterone secretion was inhibited by administering the heparinoid RO1-8307 for 12 to 18 days to 3 normal pregnant subjects. The lowering of aldosterone was accompanied by the occurrence of natriuresis in all subjects; one subject developed severe sodium depletion. It is noteworthy that natriureses occurred even though aldosterone was not reduced below normal nongravid levels and the reversal of natriureses after heparinoid treatment was stopped did not occur until aldosterone excretion had risen to much higher than normal levels. These results indicate that sodium conservation during pregnancy is dependent upon the augmented secretion of aldosterone and support the proposition that there are potent sodium-losing factors in pregnancy, which result in a compensatory increase in aldosterone secretion.