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Immunoresponse of Tissue Infiltrating Lymphocytes in Bladder Tumors

1989; Lippincott Williams & Wilkins; Volume: 141; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)41348-6

1527-3792

Hironori Tsujihashi, Hisao Matsuda, Shigeya Uejima, Takahiro Akiyama, Takashi Kurita,

Cancer Immunotherapy and Biomarkers

No AccessJournal of Urology1 Jun 1989Immunoresponse of Tissue Infiltrating Lymphocytes in Bladder Tumors Hironori Tsujihashi, Hisao Matsuda, Shigeya Uejima, Takahiro Akiyama, and Takashi Kurita Hironori TsujihashiHironori Tsujihashi More articles by this author , Hisao MatsudaHisao Matsuda More articles by this author , Shigeya UejimaShigeya Uejima More articles by this author , Takahiro AkiyamaTakahiro Akiyama More articles by this author , and Takashi KuritaTakashi Kurita More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41348-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Local immunocompetence was evaluated immunohistochemically in patients with bladder tumors before and after local injections of an immunomodulator. The subpopulations of tissue infiltrating lymphocytes (TIL) were examined by staining six serial sections with Leu4, Leu7, LeulO, LeuM3, OKT4, and OKT8 antibodies. T cells predominated over B cells in 19 of 25 bladder tumors. T cell infiltration was prominent around tumor cells, and it was marked in non-invasive tumors. B cells were rare in the stroma. In patients with low-stage tumors, OKT8 cells were more prominent than OKT4 cells. NK cells accumulated within cancer nests but their infiltration was scanty in invasive bladder tumors. Before surgery, immunomodulators (OK-432, IL-2) were injected intratumorally. Their administration resulted in marked increase of T and NK cells, irrespective of the stage of disease; there was a slight increase in B cells. These findings suggest that local immunosurveillance plays a role against bladder tumors. Further studies are required to elucidate host immune responses in the microenvironment of the cancer site, as well as the systemic immune reaction. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 141Issue 6June 1989Page: 1467-1470 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Hironori Tsujihashi More articles by this author Hisao Matsuda More articles by this author Shigeya Uejima More articles by this author Takahiro Akiyama More articles by this author Takashi Kurita More articles by this author Expand All Advertisement PDF downloadLoading ...