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Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

2016; Nature Portfolio; Volume: 18; Issue: 6 Linguagem: Inglês

10.1038/ncb3355

1476-4679

Thomas Welte, Ik Sun Kim, Lin Tian, Xia Gao, Hai Wang, June Li, Xue B. Holdman, Jason I. Herschkowitz, Adam C. Pond, Guorui Xie, Sarah J. Kurley, Tuan M. Nguyen, Lan Liao, Lacey E. Dobrolecki, Lan Pang, Qianxing Mo, Dean P. Edwards, Shixia Huang, Xin Li, Jianming Xu, Yi Li, Michael T. Lewis, Tian Wang, Thomas F. Westbrook, Jeffrey M. Rosen, Xiang H.-F. Zhang,

Cancer Cells and Metastasis

Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms governing such heterogeneity are largely unknown. Here, integrating human tumour genomics and syngeneic mammary tumour models, we demonstrate that mTOR signalling in cancer cells dictates a mammary tumour’s ability to stimulate MDSC accumulation through regulating G-CSF. Inhibiting this pathway or its activators (for example, FGFR) impairs tumour progression, which is partially rescued by restoring MDSCs or G-CSF. Tumour-initiating cells (TICs) exhibit elevated G-CSF. MDSCs reciprocally increase TIC frequency through activating Notch in tumour cells, forming a feedforward loop. Analyses of primary breast cancers and patient-derived xenografts corroborate these mechanisms in patients. These findings establish a non-canonical oncogenic role of mTOR signalling in recruiting pro-tumorigenic MDSCs and show how defined cancer subsets may evolve to promote and depend on a distinct immune microenvironment. Welte et al. report that mTOR signalling regulates G-CSF production and accumulation of myeloid-derived suppressor cells (MDSCs) to the tumour site, which promotes the tumour-initiating capacity of cancer cells by activating Notch signalling.