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Testicular Cancer Risk in Boys With Maldescended Testis: A Cohort Study

1987; Lippincott Williams & Wilkins; Volume: 138; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)43553-1

1527-3792

Aleksander Giwercman, Jacob Grindsted, Bjarne Hauge Hansen, Ole Møller Jensen, Niels E. Skakkebæk,

Sperm and Testicular Function

No AccessJournal of Urology1 Nov 1987Testicular Cancer Risk in Boys With Maldescended Testis: A Cohort Study Aleksander Giwercman, Jacob Grindsted, Bjarne Hansen, Ole M. Jensen, and Niels E. Skakkebaek Aleksander GiwercmanAleksander Giwercman , Jacob GrindstedJacob Grindsted , Bjarne HansenBjarne Hansen , Ole M. JensenOle M. Jensen , and Niels E. SkakkebaekNiels E. Skakkebaek View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43553-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Testicular maldescent is considered as a predisposing condition for development of testicular malignancy. Male subjects with a history of cryptorchidism have been suggested by some authors to have a 40 to 50 times increased risk of testis cancer. However, the magnitude of this risk is a point of considerable disagreement. Therefore, we studied the records of 506 consecutive patients hospitalized for maldescended testis from January 1949 to December 1960. Testis cancer developed in 6 patients, which when compared to the 1.3 expectant Danish incidence rate, yielded a statistically significant relative risk of 4.7 (95 per cent confidence interval 1.7 to 10.2). Thus, our study confirmed that male subjects with a history of testicular maldescent have an increased risk for testis cancer, although the magnitude of this risk was lower than suggested previously. © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byKvist K, Clasen-Linde E, Cortes D, Petersen B and Thorup J (2018) Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with CryptorchidismJournal of Urology, VOL. 191, NO. 4, (1084-1089), Online publication date: 1-Apr-2014.OH J, LANDMAN J, EVERS A, YAN Y and KIBEL A (2018) MANAGEMENT OF THE POSTPUBERTAL PATIENT WITH CRYPTORCHIDISM: AN UPDATED ANALYSISJournal of Urology, VOL. 167, NO. 3, (1329-1333), Online publication date: 1-Mar-2002.Cortes D, Thorup J, Frisch M, Møller H, Jacobsen G and Beck B (2018) Examination for Intratubular Germ Cell Neoplasia at Operation for Undescended Testis in BoysJournal of Urology, VOL. 151, NO. 3, (722-725), Online publication date: 1-Mar-1994.Giwercman A, Bruun E, Frimodt-Møller C and Skakkebaek N (2018) Prevalence of Carcinoma in Situ and other Histopathological Abnormalities in Testes of Men with a History of CryptorchidismJournal of Urology, VOL. 142, NO. 4, (998-1001), Online publication date: 1-Oct-1989.Howards S (2018) Editorial CommentsJournal of Urology, VOL. 142, NO. 4, (1001-1001), Online publication date: 1-Oct-1989.Cortes D, Thorup J and Graem N (2018) Bilateral Prepubertal Carcinoma in Situ of the Testis and Ambiguous External GenitaliaJournal of Urology, VOL. 142, NO. 4, (1065-1069), Online publication date: 1-Oct-1989.Rajfer J (2018) Editorial CommentsJournal of Urology, VOL. 142, NO. 4, (1001-1002), Online publication date: 1-Oct-1989. (2018) Reply by AuthorsJournal of Urology, VOL. 142, NO. 4, (1002-1002), Online publication date: 1-Oct-1989. Volume 138Issue 5November 1987Page: 1214-1216 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Aleksander Giwercman More articles by this author Jacob Grindsted More articles by this author Bjarne Hansen More articles by this author Ole M. Jensen More articles by this author Niels E. Skakkebaek More articles by this author Expand All Advertisement PDF downloadLoading ...