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B-Cell-Receptor-Dependent Positive and Negative Selection in Immature B Cells

2000; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-59641-4_3

2196-9965

David Nemazee, Valérie Kouskoff, W. Hertz, Julie Lang, Doron Melamed, Kathy A. Pape, Marc W. Retter,

CAR-T cell therapy research

This review touches on only a small part of the complex biology of B cells, but serves to illustrate the point that the antigen receptor is the most important of many cell-surface receptors affecting cell-fate decisions. Receptor expression is necessary, but not sufficient, for cell survival. It is also essential that a B cell's antigen-receptor specificity be appropriate for its environment. The need to balance reactivity with self tolerance has resulted in an intricate feedback control (affected by both the recombinase and cell survival) that regulates independent selection events at the level of the receptor and the cell.