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BIBTEX RIS

A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE

2016; Brazilian Chemical Society; Linguagem: Inglês

10.5935/0100-4042.20160092

ISSN

1678-7064

Autores

Laura P. Ióca, Stelamar Romminger, Mário F. C. Santos, Karin F. Bandeira, Fabiana Tessari Rodrigues, M. H. Kossuga, Karen de Jesus Nicácio, Éverton L. F. Ferreira, Raquel P. Morais‐Urano, Messias S. Passos, Luciana K. Kohn, Clarice Weis Arns, Lara Durães Sette, Roberto G. S. Berlinck,

Tópico(s)

Microbial Natural Products and Biosynthesis

Resumo

The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task.A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described.Identification was achieved by HPLC-UV-MS and 1 H NMR analyses in combination with data obtained from the Dictionary of Natural Products.Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity.(-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2-dimethyl-4-chromanone is herein reported for the first time as a natural product.

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