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Neuropeptide Y- and Vasoactive Intestinal Polypeptide-Containing Nerves in the Intrinsic External Urethral Sphincter in the Areflexic Bladder Compared to Detrusor-Sphincter Dyssynergia in Patients with Spinal Cord Injury

1987; Lippincott Williams & Wilkins; Volume: 138; Issue: 4 Part 1 Linguagem: Inglês

10.1016/s0022-5347(17)43409-4

1527-3792

P. Milner, R. Crowe, Geoffrey Burnstock, J. Keith Light,

Neuroscience of respiration and sleep

No AccessJournal of Urology1 Oct 1987Neuropeptide Y- and Vasoactive Intestinal Polypeptide-Containing Nerves in the Intrinsic External Urethral Sphincter in the Areflexic Bladder Compared to Detrusor-Sphincter Dyssynergia in Patients with Spinal Cord Injury P. Milner, R. Crowe, G. Burnstock, and J.K. Light P. MilnerP. Milner , R. CroweR. Crowe , G. BurnstockG. Burnstock , and J.K. LightJ.K. Light View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43409-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Specimens of urethra were obtained from patients with cervical and thoracic spinal cord lesion with detrusor-sphincter dyssynergia and from patients with lower motor neurone lesion with detrusor areflexia, undergoing transurethral sphincterotomy. Neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP) in nerves associated with both the smooth and striated muscle components of the urethral sphincter were studied immunohistochemically and by immunoassay. In patients with detrusor-sphincter dyssynergia following cervical and thoracic spinal cord injury, NPY- and VIP-immunoreactive varicose nerve fibres were seen in both the smooth and striated muscle components of the urethral sphincter. In the smooth muscle, NPY- and VIP-immunoreactive nerves did not appear to have any particular orientation, but in the striated muscle region they were found to run along the length of individual muscle fibres. In patients with detrusor areflexia following lower motor neurone lesion, while the pattern, density and fluorescence intensity of NPY- and VIP-immunoreactive nerves in the smooth muscle of the sphincter mechanism appeared the same as seen in patients with detrusor-sphincter dyssynergia, there was a marked increase in the density of these nerves in the striated muscle region of the sphincter mechanism. Quantitation of the peptides by immunoassay was consistent with the histochemical findings, with significantly higher levels of both NPY and VIP in the striated muscle of patients with lower motor neurone lesion, compared to those with cervical and thoracic spinal cord lesion, p = 0.04. NPY and VIP levels in urethral smooth muscle were in the same range in lower motor neurone lesion patients and cervical and thoracic spinal cord lesion patients. We conclude that there are increased NPY- and VIP-containing fibres in striated muscle of the intrinsic external urethral sphincter in patients with areflexic bladder compared with those with detrusor-sphincter dyssynergia. © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byCrowe R, Vale J, Trott K, Soediono P, Robson T and Burnstock G (2018) Radiation-Induced Changes in Neuropeptides in the Rat Urinary BladderJournal of Urology, VOL. 156, NO. 6, (2062-2066), Online publication date: 1-Dec-1996.Crowe R, Noble J, Robson T, Soediono P, Milroy E and Burnstock G (2018) An Increase of Neuropeptide Y But Not Nitric Oxide Synthase-Immunoreactive Nerves in the Bladder Neck from Male Patients with Bladder Neck DyssynergiaJournal of Urology, VOL. 154, NO. 3, (1231-1236), Online publication date: 1-Sep-1995.Light J, Beric A and Petronic I (2018) Detrusor Function with Lesions of the Cauda Equina, with Special Emphasis on the Bladder NeckJournal of Urology, VOL. 149, NO. 3, (539-542), Online publication date: 1-Mar-1993.Crowe R, Moss H, Chapple C, Light J and Burnstock G (2018) Patients with Lower Motor Spinal Cord Lesion: A Decrease of Vasoactive Intestinal Polypeptide, Calcitonin Gene-Related Peptide and Substance P, but not Neuropeptide Y and Somatostatin-Immunoreactive Nerves in the Detrusor Muscle of the BladderJournal of Urology, VOL. 145, NO. 3, (600-604), Online publication date: 1-Mar-1991.Benson G (2018) Editorial CommentJournal of Urology, VOL. 141, NO. 1, (49-49), Online publication date: 1-Jan-1989.Crowe R, Burnstock G and Light J (2018) Adrenergic Innervation of the Striated Muscle of the Intrinsic External Urethral Sphincter From Patients with Lower Motor Spinal Cord LesionJournal of Urology, VOL. 141, NO. 1, (47-49), Online publication date: 1-Jan-1989. Volume 138Issue 4 Part 1October 1987Page: 888-892 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information P. Milner More articles by this author R. Crowe More articles by this author G. Burnstock More articles by this author J.K. Light More articles by this author Expand All Advertisement PDF downloadLoading ...