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Liver histopathologic alterations in the frog Rana (Pelophylax) ridibunda induce by the action of Reldan 40EC insecticide.

2010; University of Oradea Publishing House; Volume: 17; Issue: 1 Linguagem: Inglês

1224-5119

Alina Păunescu, Cristina Maria Ponepal, O. Drăghici, Alexandru Gabriel Marinescu,

Aquaculture disease management and microbiota

Histological and histochemical alterations in the liver of the frog Rana ridibunda induced by the action of the insecticide Reldan 40EC (chlorpyrifos-methil) were investigated. The animals used in the experiment were treated with 0.01 ml/g body weight Reldan 40EC and kept at 4-6oC, respectively at 22-24oC. The toxic was administrated by intraperitoneal shots (one shot every two days, in a scheme of three weeks). At the end of the experiment we observe an increase in the area occupied by the Kuppfer cells as well as an increase in their color intensity. Mild karyomegalia and polyploidy together with accumulation of infiltrates was evident. We also observe a fibrosis around the blood vessels and between hepatocytes.