Portal de Periódicos da CAPES

Nucleoside Inhibitors of Zika Virus

2016; Oxford University Press; Volume: 214; Issue: 5 Linguagem: Inglês

10.1093/infdis/jiw226

1537-6613

Luděk Eyer, Radim Nencka, Ivana Huvarová, Martin Palus, Maria João Alves, Ernest A. Gould, Erik De Clercq, Daniel Růžek,

Virology and Viral Diseases

There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2′-C- or 2′-O-methyl–substituted nucleosides, 2′-C-fluoro-2′-C-methyl–substituted nucleosides, 3′-O-methyl–substituted nucleosides, 3′-deoxynucleosides, derivatives with 4′-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2′-C–methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.