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Spongosine Production by a Vibrio harveyi Strain Associated with the Sponge Tectitethya crypta

2015; American Chemical Society; Volume: 78; Issue: 3 Linguagem: Inglês

10.1021/np5009762

1520-6025

Matthew J. Bertin, Sarah L. Schwartz, J. Jack Lee, Anton Korobeynikov, Pieter C. Dorrestein, Lena Gerwick, William H. Gerwick,

Marine Toxins and Detection Methods

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.