Portal de Periódicos da CAPES

Forced diuresis in the management of barbiturate intoxication

1965; Wiley; Volume: 6; Issue: 6 Linguagem: Inglês

10.1002/cpt196566693

1532-6535

James C. Strickler,

Poisoning and overdose treatments

The renal excretion of barbiturates is increased in both experimental animals and in patients heavily overdosed with these sedative drugs by enhancing the urine flow. The greatest increases in excretion as a function of urine flow occur with those long‐acting and intermediate‐acting barbituric acid derivatives which are, in therapeutic dosages, eliminated in part by the kidney. Alkalinization of urine further augments the renal excretion of the compounds with relatively low pKa values. Hemodialysis and to a lesser extent peritoneal dialysis more rapidly eliminate barbiturates, particularly the short‐acting derivatives, than does any diuretic regimen.