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Morphology of Prostate Cancer: The Effects of Multifocality on Histological Grade, Tumor Volume and Capsule Penetration

1994; Lippincott Williams & Wilkins; Volume: 152; Issue: 5 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)32368-6

1527-3792

Gary J. Miller, James M. Cygan,

Molecular Biology Techniques and Applications

No AccessJournal of Urology1 Nov 1994Morphology of Prostate Cancer: The Effects of Multifocality on Histological Grade, Tumor Volume and Capsule Penetration Gary J. Miller and James M. Cygan Gary J. MillerGary J. Miller and James M. CyganJames M. Cygan View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32368-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A series of 151 radical prostatectomy specimens were subjected to whole-mount analysis. Features examined included histological grade, tumor volume, pathological stage and multifocality. Only 43.7% of the prostates contained a single carcinoma, 31.1% had 2 separate foci and the remaining 25.2% contained 3 to 6 tumors. Multifocality was greatest among tumors with the lowest mean volumes. Tumors with volumes of less than 3 cc were found in all grades (Gleason sums of 2 through 10). The highest volume tumors were those of intermediate grade (Gleason sums 4 through 8). Among tumors with volumes of less than 1 cc 70% that were confined within the prostatic capsule had Gleason sums of 4 or less. However, tumors with volumes of less than 3 cc that had invaded through the prostatic capsule were nearly equally divided between Gleason sums of 2, 3 or 4 and those of 5, 6 or 7. While studies examining the largest tumor per prostate have suggested that histological grade and volume are closely related, our results indicate that this is not necessarily the case. Furthermore, it is clear that tumors need not acquire either large volume or high grade before they can become locally invasive. It is likely, therefore, that the prediction of prognosis for patients with prostatic cancer is greatly influenced by tumor multifocality. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byFalzarano S, Zhou M, Hernandez A, Klein E, Rubin M and Magi-Galluzzi C (2018) Single Focus Prostate Cancer: Pathological Features and ERG Fusion StatusJournal of Urology, VOL. 185, NO. 2, (489-494), Online publication date: 1-Feb-2011.SCHERR D, VAUGHAN E, WEI J, CHUNG M, FELSEN D, ALLBRIGHT R and KNUDSEN B (2018) BCL-2 AND P53 EXPRESSION IN CLINICALLY LOCALIZED PROSTATE CANCER PREDICTS RESPONSE TO EXTERNAL BEAM RADIOTHERAPYJournal of Urology, VOL. 162, NO. 1, (12-17), Online publication date: 1-Jul-1999.UKIMURA O, TRONCOSO P, RAMIREZ E and BABAIAN R (2018) PROSTATE CANCER STAGING: CORRELATION BETWEEN ULTRASOUND DETERMINED TUMOR CONTACT LENGTH AND PATHOLOGICALLY CONFIRMED EXTRAPROSTATIC EXTENSIONJournal of Urology, VOL. 159, NO. 4, (1251-1259), Online publication date: 1-Apr-1998.CRAWFORD E, HIRANO D, WERAHERA P, LUCIA M, DeANTONI E, DANESHGARI F, BRAWN P, SPEIGHTS V, STEWART J and MILLER G (2018) COMPUTER MODELING OF PROSTATE BIOPSY: TUMOR SIZE AND LOCATION-NOT CLINICAL SIGNIFICANCE-DETERMINE CANCER DETECTIONJournal of Urology, VOL. 159, NO. 4, (1260-1264), Online publication date: 1-Apr-1998.HIRANO D, WERAHERA P, CRAWFORD E, LUCIA M, DeANTONI E and MILLER G (2018) MORPHOLOGICAL ANALYSIS AND CLASSIFICATION OF LATENT PROSTATE CANCER USING A 3-DIMENSIONAL COMPUTER ALGORITHM: ANALYSIS OF TUMOR VOLUME, GRADE, TUMOR DOUBLING TIME AND LIFE EXPECTANCYJournal of Urology, VOL. 159, NO. 4, (1265-1269), Online publication date: 1-Apr-1998.Crundwell M, Arkell D, Gearty J and Phillips S (2018) GENETIC ALTERATIONS IN INCIDENTALLY DIAGNOSED, TRANSITIONAL ZONE PROSTATE CANCER: A SEVEN YEAR FOLLOW-UPJournal of Urology, VOL. 158, NO. 4, (1568-1575), Online publication date: 1-Oct-1997.O'Dowd G, Veltri R, Orozco R, Miller M and Oesterling J (2018) Update on the Appropriate Staging Evaluation for Newly Diagnosed Prostate CancerJournal of Urology, VOL. 158, NO. 3, (687-698), Online publication date: 1-Sep-1997. Volume 152Issue 5 Part 2November 1994Page: 1709-1713 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordsneoplasm stagingprostatic neoplasmshistological techniquesneoplasm metastasisMetricsAuthor Information Gary J. Miller More articles by this author James M. Cygan More articles by this author Expand All Advertisement PDF downloadLoading ...