Portal de Periódicos da CAPES

Association of miR-608 rs4919510 polymorphism and cancer risk: a meta-analysis based on 13,664 subjects

2016; Impact Journals LLC; Volume: 8; Issue: 23 Linguagem: Inglês

10.18632/oncotarget.9509

1949-2553

Huiquan Liu, Ya‐Qun Zhou, Qingquan Liu, Guangqin Xiao, Bangyan Wang, Weijuan Li, Dawei Ye, Shiying Yu,

Cancer-related molecular mechanisms research

// Huiquan Liu 1 , Yaqun Zhou 2 , Qingquan Liu 3 , Guangqin Xiao 4 , Bangyan Wang 1 , Weijuan Li 1 , Dawei Ye 1 and Shiying Yu 1 1 Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2 Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 3 Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4 Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Correspondence to: Dawei Ye, email: dy0711@gmail.com Shiying Yu, email: syyu@tjh.tjmu.edu.cn Keywords: miR-608, rs4919510, polymorphism, cancer risk, meta-analysis Received: February 03, 2016 Accepted: April 16, 2016 Published: May 20, 2016 ABSTRACT Single nucleotide polymorphisms (SNPs) in MicroRNAs (miRNAs) are involved in the mechanism of carcinogenesis. Several studies have evaluated the association of rs4919510 SNP in miR-608 with cancer susceptibility in different types of cancer, with inconclusive outcomes. To obtain a more precise estimation, we carried out this meta-analysis through systematic retrieval from the PubMed and Embase database. A total of 10 case-control studies were analyzed with 6,000 cases and 7,664 controls. The results showed that 4919510 SNP in miR-608 was significantly associated with decreased cancer risk only in recessive model (CC vs. GG+GC: OR=0.89, 95% CI: 0.82-0.97, P =0.009). By further stratified analysis, we found that rs4919510 SNP had some relationship with decreased cancer risk in both homozygote model (CC vs. GG: OR=0.59, 95% CI: 0.36-0.96, P =0.034) and dominant model (CG+ CC vs. GG: OR=0.60, 95% CI: 0.37-0.98, P =0.042) in Caucasians but no relationship in any genetic model in Asians. These results indicated that miR-608 rs4919510 polymorphism may contribute to the decreased cancer susceptibility and could be a promising target to forecast cancer risk for clinical practice. However, to further confirm these results, well-designed large scale case–control studies are needed in the future.