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Malacoplakia of the Bladder: Efficacy of Bethanechol Chloride Therapy

1979; Lippincott Williams & Wilkins; Volume: 122; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)56566-0

1527-3792

David H. Zornow, Ralph R. Landes, S. Morganstern, Floyd A. Fried,

Urinary Tract Infections Management

No AccessJournal of Urology1 Nov 1979Malacoplakia of the Bladder: Efficacy of Bethanechol Chloride Therapy David H. Zornow, Ralph R. Landes, Steven L. Morganstern, and Floyd A. Fried David H. ZornowDavid H. Zornow More articles by this author , Ralph R. LandesRalph R. Landes More articles by this author , Steven L. MorgansternSteven L. Morganstern More articles by this author , and Floyd A. FriedFloyd A. Fried More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)56566-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Present evidence suggests that malacoplakia is the result of a functional defect in the mononuclear cells of the lesion caused by a deficiency of cyclic 3′,5′ guanosine monophosphate. This defect results in the impaired ability of the macrophage to release lysosomal enzymes necessary for the digestion of phagocytized bacteria. The persistent inflammatory reaction produces the characteristic granuloma of malacoplakia. Previous laboratory studies indicate that the phagocytic defect is reversible by cholinergic agonists, which led to the use of bethanechol chloride in the treatment of patients with malacoplakia, We report on 3 patients with vesical malacoplakia who were treated successfully with bethanechol chloride. © 1979 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byHurwitz G, Reimund E, Moparty K and Hellstrom W (2018) Bilateral Renal Parenchymal Malacoplakia: A Case ReportJournal of Urology, VOL. 147, NO. 1, (115-117), Online publication date: 1-Jan-1992.Long J and Althausen A (2018) Malacoplakia: A 25-Year Experience with a Review of the LiteratureJournal of Urology, VOL. 141, NO. 6, (1328-1331), Online publication date: 1-Jun-1989.Dubey N, Tavadia H and Hehir M (2018) Malacoplakia: A Case Involving Epididymis and a Case Involving a Bladder Complicated by CalculiJournal of Urology, VOL. 139, NO. 2, (359-361), Online publication date: 1-Feb-1988.Matthews P, Greenwood R, Hendry W and Cattell W (2018) Extensive Pelvic Malacoplakia: Observations on ManagementJournal of Urology, VOL. 135, NO. 1, (132-134), Online publication date: 1-Jan-1986.Witherington R, Branan W, Wray B and Best G (2018) Malacoplakia Associated with Vesicoureteral Reflux and Selective Immunoglobulin a DeficiencyJournal of Urology, VOL. 132, NO. 5, (975-977), Online publication date: 1-Nov-1984.Streem S (2018) Genitourinary Malacoplakia in Renal Transplant Recipients: Pathogenic, Prognostic and Therapeutic ConsiderationsJournal of Urology, VOL. 132, NO. 1, (10-12), Online publication date: 1-Jul-1984.Stanton M, Lynch J, Maxted W and Chun B (2018) Malacoplakia of the Bladder: A Case Report of Resolution with Bethanechol, Trimethoprim-Sulfamethoxazole and Ascorbic AcidJournal of Urology, VOL. 130, NO. 6, (1174-1175), Online publication date: 1-Dec-1983.Stanton M and Maxted W (2018) Malacoplakia: A Study of the Literature and Current Concepts of Pathogenesis, Diagnosis and TreatmentJournal of Urology, VOL. 125, NO. 2, (139-146), Online publication date: 1-Feb-1981. Volume 122Issue 5November 1979Page: 703-704 Advertisement Copyright & Permissions© 1979 by The American Urological Association Education and Research, Inc.MetricsAuthor Information David H. Zornow More articles by this author Ralph R. Landes More articles by this author Steven L. Morganstern More articles by this author Floyd A. Fried More articles by this author Expand All Advertisement PDF downloadLoading ...