Portal de Periódicos da CAPES

[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder

1995; American Psychiatric Association; Volume: 152; Issue: 9 Linguagem: Inglês

10.1176/ajp.152.9.1359

1535-7228

Robert T. Malison, Christopher J. McDougle, Christopher H. van Dyck, Lawrence David Scahill, Ronald M. Baldwin, John Seibyl, Lawrence H. Price, James F. Leckman, Robert B. Innis,

Neurotransmitter Receptor Influence on Behavior

The authors examined whether subjects with Tourette's disorder have greater than normal striatal dopamine transporter densities, as suggested by previous post-mortem findings.Single photon emission computed tomography (SPECT) and [123I]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123I]beta-CIT) were used to assess dopamine transporter levels in five adult patients with Tourette's disorder and five age- and gender-matched healthy comparison subjects.Striatal [123I]beta-CIT binding was a mean of 37% (range = 6%-79%) higher in the subjects with Tourette's disorder than in the comparison subjects, and each Tourette's disorder patient had a higher level than his or her paired comparison subject.These findings corroborate post-mortem results and support the hypothesis of a dysregulation in presynaptic dopamine function in Tourette's disorder.