Portal de Periódicos da CAPES

The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice

2015; American Chemical Society; Volume: 9; Issue: 8 Linguagem: Inglês

10.1021/acsnano.5b00042

1936-086X

Jelena Kolosnjaj‐Tabi, Yasir Javed, Lénaïc Lartigue, Jeanne Volatron, Dan Elgrabli, Iris Marangon, Giammarino Pugliese, Benoît Caron, Albert Figuerola, Nathalie Luciani, Teresa Pellegrino, Damien Alloyeau, Florence Gazeau,

Nanoparticle-Based Drug Delivery

Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.