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A Comparative Study of the Treatment of Urinary Infection

1969; SAGE Publishing; Volume: 14; Issue: 3 Linguagem: Inglês

10.1177/003693306901400302

2045-6441

A. C. Kennedy, M. E. M. Allison, J. D. Briggs, J. McGeachie,

Bladder and Urothelial Cancer Treatments

Fifty-five female patients aged 12 to 76 years were found to have a significant urinary tract infection on culture of 2 or more consecutive mid-stream specimens of urine (i.e. over 100,000 organisms/ml.). Ninety per cent were due to Escherichia coli and 50 per cent were asymptomatic. A comparative study of the value of 4 regimes (alkali alone, sulphonamide plus alkali, streptomycin plus alkali, nitrofurantoin) in eradicating the initial infection and on the recurrence rate was carried out. Alkali alone had no effect on bacteriuria, nitrofurantoin had a 100 per cent 5-day sterility rate, while sulphonamide and streptomycin had 85 and 88 per cent 5-day sterility rates respectively, differences which are not statistically significant. All of the failures had E. coli infections, none had pyelographic evidence of pyelonephritis or had an elevated blood urea, and only 2 had an antibody titre against the infecting organism over 1/320. There was an overall recurrence rate, mainly due to re-infection, of 53 per cent within the first 6 months. Sulphonamide therapy seemed associated with a lower recurrence rate than nitrofurantoin or streptomycin but the numbers involved are too small to allow statistical evaluation.