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Intestinal bacterial origin of d -alanine in urine of mutant mice lacking d -amino-acid oxidase

1990; Portland Press; Volume: 268; Issue: 2 Linguagem: Inglês

10.1042/bj2680263

1470-8728

Ryo Konno, Akira Niwa, Y Yasumura,

Metabolism and Genetic Disorders

Urine from mutant mice which lack D-amino-acid oxidase contained a large amount of D-alanine. The alanine content was not changed by changes in the dietary composition or by starvation. However, oral administration of an antibiotic, amoxicillin, decreased the urinary alanine to the normal level. These results suggest that the D-alanine is not of dietary origin but of intestinal bacterial origin.