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Mediators of fibrinolysis in orthotopic liver transplantation

1996; Wiley; Volume: 10; Issue: 1pt1 Linguagem: Inglês

10.1111/j.1399-0012.1996.tb00639.x

1399-0012

Surinder P. S. Cheema, Nigel R. Webster, Fiona Dunn, Mark C. Bellamy,

Liver Disease Diagnosis and Treatment

Activation of fibrinolysis remains a clinical problem in orthotopic liver transplantation. We have measured tissue plasminogen activator (t‐PA), plasmin and α‐2‐anti‐plasmin (α2AP) activities in plasma from 10 patients undergoing elective transplantation. t‐PA activity increased during the anhepatic phase and immediately after graft reperfusion (p>0.001). This inrease could not be attributed to t‐PA released by the donor liver. Overall transfusion requirements did not relate with either t‐ PA or α2AP activities individually, but were strongly correlated with the ratio t‐PA/ α2AP (p>0.02). These results suggest that routine prophylactic use of antifibrinolytic agents may be beneficial.