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Complement Activation in Dialysis: Effects on Cytokines, Lymphocyte Activation and β 2 Microglobulin

1994; SAGE Publishing; Volume: 17; Issue: 6 Linguagem: Inglês

10.1177/039139889401700605

1724-6040

M. Gardinali, Anna Maria Calcagno, L. Conciato, A Agostoni, Alberto Rosti, P. Cori, Nadia Vozzo, A. Moroni, A. Anelli, U. Zoni, M. Del Prete,

Neurological Complications and Syndromes

Anaphylatoxins generated by complement activation by filter membranes are present in plasma during hemodialysis (HD). In the presence of endotoxins which may contaminate the dialysate, they can trigger monocytes to produce interleukin-1 (IL-1) and tumor necrosis factor (TNF), with detrimental effects for the patients. We have investigated whether or not the use of complement activating (cuprophan) and non- (or less-) activating membranes (polysulfone, polymethylmethacrylate or polyacrylonitrile) per se influences cytokine levels in HD patients. Our results indicate that if a sterile bicarbonate solution is used as dialysate, there are no significant increases in IL-1, TNF, interleukin-2 (IL-2) and soluble IL-2 receptors (sIL-2r) throughout HD, even with cuprophan membranes. Moreover even a prolonged use of this membrane (three months) did not change pre-dialysis levels of cytokines and receptors. Use of complement activating membranes also does not influence β 2 microglobulin levels.