Spiegelmers: Biostable Aptamers
2003; Wiley; Volume: 4; Issue: 10 Linguagem: Inglês
10.1002/cbic.200300663
ISSN1439-7633
Autores Tópico(s)RNA Interference and Gene Delivery
ResumoChemBioChemVolume 4, Issue 10 p. 979-983 Minireview Spiegelmers: Biostable Aptamers Dirk Eulberg Dr., Dirk Eulberg Dr. NOXXON Pharma AG, Max-Dohrn-Strasse 8 – 10, 10589 Berlin, Germany, Fax: (+49) 30-726247-243Search for more papers by this authorSven Klussmann Dr., Sven Klussmann Dr. [email protected] NOXXON Pharma AG, Max-Dohrn-Strasse 8 – 10, 10589 Berlin, Germany, Fax: (+49) 30-726247-243Search for more papers by this author Dirk Eulberg Dr., Dirk Eulberg Dr. NOXXON Pharma AG, Max-Dohrn-Strasse 8 – 10, 10589 Berlin, Germany, Fax: (+49) 30-726247-243Search for more papers by this authorSven Klussmann Dr., Sven Klussmann Dr. [email protected] NOXXON Pharma AG, Max-Dohrn-Strasse 8 – 10, 10589 Berlin, Germany, Fax: (+49) 30-726247-243Search for more papers by this author First published: 26 September 2003 https://doi.org/10.1002/cbic.200300663Citations: 124Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Not from this world: Mirror-image nucleic acids are made of L-nucleotides instead of natural D-nucleotides. Just like natural D-nucleic acids, single-stranded L-oligonucleotides can fold into distinct 3D structures and are thus capable of tightly and specifically binding to a given target (see picture). As a result of their non-natural chirality, such "spiegelmers" are not substrates for nucleases and therefore persist even in body fluids. Citing Literature Volume4, Issue10Special Issue: RNA Special IssueOctober 6, 2003Pages 979-983 RelatedInformation
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