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The Natural History of Papillary Transitional Cell Carcinoma of the Bladder and its Treatment in an Unselected Population on the Basis of Histologic Grading

1978; Lippincott Williams & Wilkins; Volume: 119; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(17)57526-6

1527-3792

Harvey A. Gilbert, J.L. Logan, A. Robert Kagan, Henry Friedman, J.K. Cove, M. Fox, Thomas Muldoon, Yvonne Lonni, Jared Rowe, J. Fenimore Cooper, Herman Nussbaum, P. Chan, A. Rao, Adam Starr,

Urological Disorders and Treatments

No AccessJournal of Urology1 Apr 1978The Natural History of Papillary Transitional Cell Carcinoma of the Bladder and its Treatment in an Unselected Population on the Basis of Histologic Grading H.A. Gilbert, J.L. Logan, A.R. Kagan, H.A. Friedman, J.K. Cove, M. Fox, T.M. Muldoon, Y.W. Lonni, J.H. Rowe, J.F. Cooper, H. Nussbaum, P. Chan, A. Rao, and A. Starr H.A. GilbertH.A. Gilbert More articles by this author , J.L. LoganJ.L. Logan More articles by this author , A.R. KaganA.R. Kagan More articles by this author , H.A. FriedmanH.A. Friedman More articles by this author , J.K. CoveJ.K. Cove More articles by this author , M. FoxM. Fox More articles by this author , T.M. MuldoonT.M. Muldoon More articles by this author , Y.W. LonniY.W. Lonni More articles by this author , J.H. RoweJ.H. Rowe More articles by this author , J.F. CooperJ.F. Cooper More articles by this author , H. NussbaumH. Nussbaum More articles by this author , P. ChanP. Chan More articles by this author , A. RaoA. Rao More articles by this author , and A. StarrA. Starr More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)57526-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Between 1950 and 1965, 365 patients were treated for transitional cancer of the bladder at our hospitals. A retrospective study was done, using clinical records and a histopathologic review to determine the long-term natural history of this population when treated conservatively. The natural history of 3 separate patient populations was discovered, based solely on the grading of the transurethrally resected fragments. Based on the grade on initial presentation these patients were divided into grades I, II and III. Of the patients 5 per cent in grade I, 16 per cent in grade II, 28 to 35 per cent in grade III not involving muscle and 83 per cent in grade III involving muscle died of bladder cancer. Ninety-seven patients (26 per cent) died of bladder cancer, 110 (31 per cent) died of other causes and 158 (43 per cent) have been alive more than 5 years (104 more than 10 years). Grade I tumors that progressed to a higher grade did so within 2 years of the initial diagnosis. Of the bladder cancer deaths 83 per cent occurred within 2 years of the initial diagnosis. Of 64 patients dying more than 5 years after presentation only 7 died of bladder cancer. © 1978 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byUCHIO E, LINEHAN W, FIGG W and WALTHER M (2018) A Phase I Study of Intravesical Suramin for the Treatment of Superficial Transitional Cell Carcinoma of the BladderJournal of Urology, VOL. 169, NO. 1, (357-360), Online publication date: 1-Jan-2003.LOUGHLIN K, MANSON K, CRAGNALE D, WILSON L, BALL R and BRIDGES K (2018) THE USE OF HYDROGEN PEROXIDE TO ENHANCE THE EFFICACY OF DOXORUBICIN HYDROCHLORIDE IN A MURINE BLADDER TUMOR CELL LINEJournal of Urology, VOL. 165, NO. 4, (1300-1304), Online publication date: 1-Apr-2001.KIM J and STEINBERG G (2018) THE LIMITS OF BACILLUS CALMETTE-GUERIN FOR CARCINOMA IN SITU OF THE BLADDERJournal of Urology, VOL. 165, NO. 3, (745-756), Online publication date: 1-Mar-2001.LEBRET T, BOHIN D, KASSARDJIAN Z, HERVE J, MOLINIE V, BARRE P, LUGAGNE P and BOTTO H (2018) RECURRENCE, PROGRESSION AND SUCCESS IN STAGE TA GRADE 3 BLADDER TUMORS TREATED WITH LOW DOSE BACILLUS CALMETTE-GUERIN INSTILLATIONSJournal of Urology, VOL. 163, NO. 1, (63-67), Online publication date: 1-Jan-2000.Stampfer D, Carpinito G, Rodriquez-Villanueva J, Willsey L, Dinney C, Grossman H, Fritsche H and McDougal W (2018) EVALUATION OF NMP22 IN THE DETECTION OF TRANSITIONAL CELL CARCINOMA OF THE BLADDERJournal of Urology, VOL. 159, NO. 2, (394-398), Online publication date: 1-Feb-1998.Tanaka Y, Kawamata H, Fujimoto K and Oyasu R (2018) Angiogenesis Inhibitor TNP-470 Suppresses Tumorigenesis In Rat Urinary BladderJournal of Urology, VOL. 157, NO. 2, (683-688), Online publication date: 1-Feb-1997.Giannopoulos A, Constantinides C, Kortsaris A, Chrisofos M, Pavlaki C and Dimopoulos C (2018) Determination of Interferon-alpha Receptors in Urothelial Cancer and in Normal UrotheliumJournal of Urology, VOL. 157, NO. 1, (79-82), Online publication date: 1-Jan-1997.Hurle R, Losa A, Ranieri A, Graziotti P and Lembo A (2018) Low Dose Pasteur Bacillus Calmette-Guerin Regimen in Stage T1, Grade 3 Bladder Cancer TherapyJournal of Urology, VOL. 156, NO. 5, (1602-1605), Online publication date: 1-Nov-1996.Holmang S, Hedelin H, Anderstrom C and Johansson S (2018) The Relationship Among Multiple Recurrences, Progression and Prognosis of Patients with Stages TA and T1 Transitional Cell Cancer of the Bladder Followed for at least 20 yearsJournal of Urology, VOL. 153, NO. 6, (1823-1827), Online publication date: 1-Jun-1995.Yoshimura I, Kudoh J, Saito S, Tazaki H and Shimizu N (2018) p53 Gene Mutation in Recurrent Superficial Bladder CancerJournal of Urology, VOL. 153, NO. 5, (1711-1715), Online publication date: 1-May-1995. 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Volume 119 Issue 4 April 1978 Page: 488-492 Advertisement Copyright & Permissions© 1978 by The American Urological Association Education and Research, Inc.Metrics Author Information H.A. Gilbert More articles by this author J.L. Logan More articles by this author A.R. Kagan More articles by this author H.A. Friedman More articles by this author J.K. Cove More articles by this author M. Fox More articles by this author T.M. Muldoon More articles by this author Y.W. Lonni More articles by this author J.H. Rowe More articles by this author J.F. Cooper More articles by this author H. Nussbaum More articles by this author P. Chan More articles by this author A. Rao More articles by this author A. Starr More articles by this author Expand All Advertisement PDF downloadLoading ...