Metabolic and Immunological Effects of Antiretroviral Agents in Healthy Individuals Receiving Post-Exposure Prophylaxis
2002; SAGE Publishing; Volume: 7; Issue: 3 Linguagem: Inglês
10.1177/135965350200700309
ISSN2040-2058
AutoresFelipe García, Montserrat Plana, Gabriel Mestre, Anna Cruceta, Estebán Martínez, José M. Miró, Josep Mallolas, Montserrat Tuset, Tomàs Pumarola, Teresa Gallart, José M. Gatell,
Tópico(s)HIV/AIDS drug development and treatment
ResumoWe have assessed metabolic and immunological effects of a nelfinavir-containing regimen in healthy HIV-1-uninfected individuals receiving post-exposure prophylaxis. Our data suggest that this regimen is well tolerated and did not modify the lipid or hepatic profiles. This antiretroviral regimen seems to have no effect on lymphocyte T cell subsets, however, it could have an immune-modulator role, inducing an increase in the proliferative responses to mitogens.
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