Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases
2015; Baishideng Publishing Group; Volume: 21; Issue: 24 Linguagem: Inglês
10.3748/wjg.v21.i24.7584
ISSN2219-2840
Autores Tópico(s)Systemic Lupus Erythematosus Research
ResumoThis article describes cases of anti-tumor necrosis factor (TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy.A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis (AIH) associated with anti-TNF biologic agents.We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab.A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease.Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH.The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended.Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with CASE REPORT 7584
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